Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma
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چکیده
منابع مشابه
Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma
Introduction. Uveal melanoma (UM) is an intraocular tumor that leads to metastatic disease in approximately 50% of afflicted patients. There is no efficacious treatment for metastatic disease in this cancer. Identification of markers that can offer prognostic and therapeutic value is a major focus in this field at present. KAI1 is a metastasis suppressor gene that has been reported to play a ro...
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AIMS To determine the expression of breast metastasis suppressor 1 (BRMS1) in human uveal melanoma (UM) tissues and cell lines. In addition, we intend to establish a possible association between BRMS1 expression and the presence of metastatic disease. METHODS Thirty-one formalin-fixed paraffin-embedded tissues from enucleated eyes of patients with UM were immunostained. Clinical-pathological ...
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متن کاملThe expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53.
KAI1 is a tumor metastasis suppressor gene that is capable of inhibiting the metastatic process in animals. The expression of the KAI1 gene also is found to be down-regulated during the tumor progression of prostate, breast, lung, bladder, and pancreatic cancers in humans, and this down-regulation appears to be at or posttranscription level. We have found that the tumor suppressor gene p53 can ...
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ژورنال
عنوان ژورنال: Journal of Ophthalmology
سال: 2013
ISSN: 2090-004X,2090-0058
DOI: 10.1155/2013/683963